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McAdam Explore JCM View Latest Content View the Series View COVID-19 (SARS-CoV-2) Special Collection Editor in Chief Dr. Alexander J. McAdam Editor in Chief (2025) | Boston Children’s Hospital Alexander J. McAdam is the Medical Director of the Infectious Diseases Diagnostic Laboratory and Vice-Chair of the Department of Laboratory Medicine at Boston Children’s Hospital and an Associate Professor of Pathology at Harvard Medical School. His research is on the utility of diagnostic tests for infectious diseases in children. Editorial Board Most Read Most Cited Journal of Clinical Microbiology Article December 2020 Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study David E. Tabor , Fiona Fernandes , Annefleur C. Langedijk , Deidre Wilkins , Robert Jan Lebbink , Andrey Tovchigrechko , Alexey Ruzin , Leyla Kragten-Tabatabaie , Hong Jin , Mark T. Esser , Louis J. Bont , Michael E. Abram and the INFORM-RSV Study Group Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study Authors : David E. Tabor , Fiona Fernandes , Annefleur C. Langedijk , Deidre Wilkins , Robert Jan Lebbink , Andrey Tovchigrechko , Alexey Ruzin , … Show All … , Leyla Kragten-Tabatabaie , Hong Jin , Mark T. Esser , Louis J. Bont , Michael E. Abram https://orcid.org/0000-0002-6505-7281 , and the INFORM-RSV Study Group Show Fewer DOI : https://doi.org/10.1128/JCM.01828-20 • Volume 59 , Number 1 17 December 2020 ABSTRACT REFERENCES ABSTRACT Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia). RSV B (all BA9 genotype) predominated over RSV A (all ON1 genotype) globally (69.0% versus 31.0%) and in all countries except South Africa. Geographic clustering patterns highlighted wide transmission and continued evolution with viral spread. Most RSV strains were from infants of <1 year of age (81.2%), males (56.3%), and patients hospitalized for >24 h (70.5%), with no differences in subtype distribution. Compared to 2013 reference sequences, variations at F protein antigenic sites were observed for both RSV A and B strains, with high-frequency polymorphisms at antigenic site Ø (I206M/Q209R) and site V (L172Q/S173L/K191R) in RSV B strains. The INFORM-RSV 2017–2018 pilot season establishes an important molecular baseline of RSV strain distribution and sequence variability with which to track the emergence of new strains and provide an early warning system of neutralization escape variants that may impact transmission or the effectiveness of vaccines and MAbs under development. REFERENCES 1. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D, Grijalva CG, Zhu Y, Szilagyi P. 2009. The burden of respiratory syncytial virus infection in young children. N Engl J Med 360:588–598. Crossref PubMed Google Scholar 2. 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Obando-Pacheco P, Justicia-Grande AJ, Rivero-Calle I, Rodriguez-Tenreiro C, Sly P, Ramilo O, Mejias A, Baraldi E, Papadopoulos NG, Nair H, Nunes MC, Kragten-Tabatabaie L, Heikkinen T, Greenough A, Stein RT, Manzoni P, Bont LJ, Martinon-Torres F. 2018. Respiratory syncytial virus seasonality: a global overview. J Infect Dis 217:1356–1364. Crossref PubMed Google Scholar 4. Broberg EK, Waris M, Johansen K, Snacken R, Penttinen P, Network EIS. 2018. Seasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016. Euro Surveill 23:17-00284. Crossref Google Scholar 5. Simoes EAF. 2003. Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease. The J Pediatrics 143:118–126. Crossref Google Scholar 6. Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EAF, Knezevic I, Ramilo O, Piedra PA, ...