jcm.asm.orgJournal of Clinical Microbiology Journal Homepage

Request Username Can’t sign in? Forgot your username? Enter your email address below and we will send you your username Email* Close If the address matches an existing account you will receive an email with instructions to retrieve your username Create a new account Email Returning user Change Password Old Password New Password Too Short Weak Medium Strong Very Strong Too Long Password Changed Successfully Your password has been changed Login Register Email* Password* Forgot password? Reset it here Keep me logged in Fields with * are mandatory Don&apost have an account? Create one here Email* Fields with * are mandatory Already have an account? Login here Can’t sign in? Forgot your password? Enter your email address below and we will send you the reset instructions Email* Retype the code from the picture: Cancel If the address matches an existing account you will receive an email with instructions to reset your password. Close Verify Phone Enter the verification code Cancel Congrats! Your Phone has been verified close CLOSE This Journal Anywhere Enter words / phrases / DOI / ISBN / keywords / authors / etc Search Search Enter words / phrases / DOI / ISBN / keywords / authors / etc Search Search Advanced search Suggested Terms: author information migration information publication fees COVID-19 collection asm journals collections BACK Antimicrobial Agents and Chemotherapy Applied and Environmental Microbiology Clinical and Vaccine Immunology Clinical Microbiology Reviews EcoSal Plus Eukaryotic Cell Infection and Immunity Journal of Bacteriology Journal of Clinical Microbiology Journal of Microbiology & Biology Education Journal of Virology mBio Microbiology and Molecular Biology Reviews Microbiology Resource Announcements Microbiology Spectrum Molecular and Cellular Biology mSphere mSystems 0 Login ASM Member Login Non-Member Login Institutional Login RegisterJOURNAL HOME ARTICLES CURRENT ISSUE ACCEPTED MANUSCRIPTS COLLECTIONS ARCHIVE FOR AUTHORS SUBMITTING WRITING YOUR PAPER TRANSFERRING ACCEPTED PAPERS EDITORIAL POLICIES PUBLISHING ETHICS ABOUT THE JOURNAL ABOUT JCM SUBMIT SCOPE EDITORIAL BOARD ARTICLE TYPES SUBMISSION AND REVIEW PROCESS FOR REVIEWERS PODCAST FAQ CONTACT US SUBSCRIBE MEMBERS INSTITUTIONS ALERTS RSS Journal of Clinical Microbiology 30 Average Days in Review 96% Percent of Research Articles Cited within Two Years of Publication 9 Average Days to Publication from Acceptance 10,197,502 Annual HTML+PDF Usage ASM Journals Journal of Clinical Microbiology View CURRENT ISSUE Volume 59 Issue 7 June 2021 View Current Issue Get alerts EDITOR IN CHIEF : Dr. Alexander J. McAdam Explore JCM View Latest Content View the Series View COVID-19 (SARS-CoV-2) Special Collection Editor in Chief Dr. Alexander J. McAdam Editor in Chief (2025) | Boston Children’s Hospital Alexander J. McAdam is the Medical Director of the Infectious Diseases Diagnostic Laboratory and Vice-Chair of the Department of Laboratory Medicine at Boston Children’s Hospital and an Associate Professor of Pathology at Harvard Medical School. His research is on the utility of diagnostic tests for infectious diseases in children. Editorial Board Most Read Most Cited Journal of Clinical Microbiology Article December 2020 Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study David E. Tabor , Fiona Fernandes , Annefleur C. Langedijk , Deidre Wilkins , Robert Jan Lebbink , Andrey Tovchigrechko , Alexey Ruzin , Leyla Kragten-Tabatabaie , Hong Jin , Mark T. Esser , Louis J. Bont , Michael E. Abram and the INFORM-RSV Study Group Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017−2018 INFORM-RSV Study Authors : David E. Tabor , Fiona Fernandes , Annefleur C. Langedijk , Deidre Wilkins , Robert Jan Lebbink , Andrey Tovchigrechko , Alexey Ruzin , … Show All … , Leyla Kragten-Tabatabaie , Hong Jin , Mark T. Esser , Louis J. Bont , Michael E. Abram https://orcid.org/0000-0002-6505-7281 , and the INFORM-RSV Study Group Show Fewer DOI : https://doi.org/10.1128/JCM.01828-20 • Volume 59 , Number 1 17 December 2020 ABSTRACT REFERENCES ABSTRACT Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular epidemiology of RSV in children under 5 years of age by monitoring temporal and geographical evolution of current circulating RSV strains, F protein antigenic sites, and their relationships with clinical features of RSV disease. During the pilot season (2017–2018), 410 RSV G-F gene sequences were obtained from 476 RSV-positive nasal samples collected from 8 countries (United Kingdom, Spain, The Netherlands, Finland, Japan, Brazil, South Africa, and Australia). RSV B (all BA9 genotype) predominated over RSV A (all ON1 genotype) globally (69.0% versus 31.0%) and in all countries except South Africa. Geographic clustering patterns highlighted wide transmission and continued evolution with viral spread. Most RSV strains were from infants of 1 year of age (81.2%), males (56.3%), and patients hospitalized for 24 h (70.5%), with no differences in subtype distribution. Compared to 2013 reference sequences, variations at F protein antigenic sites were observed for both RSV A and B strains, with high-frequency polymorphisms at antigenic site Ø (I206M/Q209R) and site V (L172Q/S173L/K191R) in RSV B strains. The INFORM-RSV 2017–2018 pilot season establishes an important molecular baseline of RSV strain distribution and sequence variability with which to track the emergence of new strains and provide an early warning system of neutralization escape variants that may impact transmission or the effectiveness of vaccines and MAbs under development. REFERENCES 1. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, Auinger P, Griffin MR, Poehling KA, Erdman D, Grijalva CG, Zhu Y, Szilagyi P. 2009. The burden of respiratory syncytial virus infection in young children. N Engl J Med 360:588–598. Crossref PubMed Google Scholar 2. Shi T, McAllister DA, O’Brien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, Alassani I, Ali A, Antonio M, Awasthi S, Awori JO, Azziz-Baumgartner E, Baggett HC, Baillie VL, Balmaseda A, Barahona A, Basnet S, Bassat Q, Basualdo W, Bigogo G, Bont LJ, Breiman RF, Brooks WA, Broor S, Bruce N, Bruden D, Buchy P, Campbell S, Carosone-Link P, Chadha M, Chipeta J, Chou M, Clara W, Cohen C, de Cuellar E, Dang D-A, Dash-Yandag B, Deloria-Knoll M, Dherani M, Eap T, Ebruke BE, Echavarria M, de Freitas Lázaro Emediato CC, Fasce RA, Feikin DR, Feng L, et al. 2017. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet 390:946–958. Crossref PubMed Google Scholar 3. Obando-Pacheco P, Justicia-Grande AJ, Rivero-Calle I, Rodriguez-Tenreiro C, Sly P, Ramilo O, Mejias A, Baraldi E, Papadopoulos NG, Nair H, Nunes MC, Kragten-Tabatabaie L, Heikkinen T, Greenough A, Stein RT, Manzoni P, Bont LJ, Martinon-Torres F. 2018. Respiratory syncytial virus seasonality: a global overview. J Infect Dis 217:1356–1364. Crossref PubMed Google Scholar 4. Broberg EK, Waris M, Johansen K, Snacken R, Penttinen P, Network EIS. 2018. Seasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016. Euro Surveill 23:17-00284. Crossref Google Scholar 5. Simoes EAF. 2003. Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease. The J Pediatrics 143:118–126. Crossref Google Scholar 6. Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EAF, Knezevic I, Ramilo O, Piedra...